BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
N-t-BOC-cis-4-hydroxy-D-proline
CAS: 135042-12-5
Molecular Formula: C10H17NO5
BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID - Names and Identifiers
| Name | N-t-BOC-cis-4-hydroxy-D-proline |
| Synonyms | BOC-D-CISHYP-OH Boc-cis-4-Hydroxy-D-proline BOC-CIS-4-HYDROXY-D-PROLINE N-BOC-CIS-4-HYDROXY-D-PROLINE N-BOC-CIS-6-HYDROXY-D-PROLINE N-t-BOC-cis-4-hydroxy-D-proline N-T-BOC-CIS-4-HYDROXY-D-PROLINE N-ALPHA-BUTOXYCARBONYL-CIS-4-HYDROXY-D-PROLINE (4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline (2R,4R)-N-Boc-4-Hydroxypyrrolidine-2-Carboxylic Acid BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID (2R,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID |
| CAS | 135042-12-5 |
| EINECS | 621-971-2 |
| InChI | InChI=1/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m1/s1 |
| InChIKey | BENKAPCDIOILGV-RNFRBKRXSA-N |
BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID - Physico-chemical Properties
| Molecular Formula | C10H17NO5 |
| Molar Mass | 231.25 |
| Density | 1.312 |
| Melting Point | 146-151 °C |
| Boling Point | 390.9±42.0 °C(Predicted) |
| Specific Rotation(α) | +48～+52°(c=0.67,MeOH,24℃) |
| Flash Point | 190.2°C |
| Vapor Presure | 9.99E-08mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| pKa | 3.80±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.531 |
BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Hazard Class | IRRITANT |
BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID - Introduction
n-Boc-cis-4-hydroxy-D-proline is an organic compound with the following properties:
1. Appearance: n-Boc-cis-4-hydroxy-D-proline is a colorless crystalline powder.
2. Solubility: It is soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
3. Chemical properties: It is an amino acid with hydroxyl functional group and protecting group (Boc), which can be used to synthesize other organic compounds.
The use of n-Boc-cis -4-hydroxy-D-proline is mainly used in the field of organic synthesis, especially in the application of drug synthesis.
The method for preparing n-Boc-cis-4-hydroxy-D-proline is as follows:
1. Synthesis of L-tyrosine. Acetyl formaldehyde was first prepared by acetal reaction of acetophenone or phenylacetyl chloride and formaldehyde, then it was reacted with dichloroethane and lithium bromide to produce benzyl ethanol, and finally L-tyrosine was prepared by diazotization reaction.
2. Synthesis of n-Boc-cis -4-hydroxy-D-proline. Acylation of L-tyrosine with isobutylene anhydride followed by protection of the acyl group with acetic anhydride and finally by protection of the hydroxyl group and deprotonation yields n-Boc-cis-4-hydroxy-D-proline.
Regarding safety information, n-Boc-cis-4-hydroxy-D-proline may cause irritation to the skin, eyes and respiratory system. Immediately after contact, rinse with plenty of water and seek medical advice. Wear protective glasses, protective gloves and protective masks during use to avoid inhalation of dust or skin contact. In addition, the compound should be kept away from fire and oxidizing agents and stored in a dry, cool place.
1. Appearance: n-Boc-cis-4-hydroxy-D-proline is a colorless crystalline powder.
2. Solubility: It is soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
3. Chemical properties: It is an amino acid with hydroxyl functional group and protecting group (Boc), which can be used to synthesize other organic compounds.
The use of n-Boc-cis -4-hydroxy-D-proline is mainly used in the field of organic synthesis, especially in the application of drug synthesis.
The method for preparing n-Boc-cis-4-hydroxy-D-proline is as follows:
1. Synthesis of L-tyrosine. Acetyl formaldehyde was first prepared by acetal reaction of acetophenone or phenylacetyl chloride and formaldehyde, then it was reacted with dichloroethane and lithium bromide to produce benzyl ethanol, and finally L-tyrosine was prepared by diazotization reaction.
2. Synthesis of n-Boc-cis -4-hydroxy-D-proline. Acylation of L-tyrosine with isobutylene anhydride followed by protection of the acyl group with acetic anhydride and finally by protection of the hydroxyl group and deprotonation yields n-Boc-cis-4-hydroxy-D-proline.
Regarding safety information, n-Boc-cis-4-hydroxy-D-proline may cause irritation to the skin, eyes and respiratory system. Immediately after contact, rinse with plenty of water and seek medical advice. Wear protective glasses, protective gloves and protective masks during use to avoid inhalation of dust or skin contact. In addition, the compound should be kept away from fire and oxidizing agents and stored in a dry, cool place.
Last Update：2024-04-09 20:52:54
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CAS: 135042-12-5
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CAS: 135042-12-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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